Record Details

The Safar Center for Resuscitation Research: Searching for Breakthroughs in the New Millennium

General Reanimatology

View Archive Info
 
 
Field Value
 
Title The Safar Center for Resuscitation Research: Searching for Breakthroughs in the New Millennium
The Safar Center for Resuscitation Research: Searching for Breakthroughs in the New Millennium
 
Creator P. Kochanek M.; Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USA
H. Bayir ; Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USA
R. Berger P.; Department of Pediatrics Children's Hospital of Pittsburgh Pittsburgh, Pennsylvania, USA
C. Dixon E.; Department of Neurological Surgery University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USA
L. Jenkins ; Department of Neurological Surgery University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USA
A. Kline E.; Department of Neurological Surgery University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USA
S. Tisherman ; Departments of Surgery and Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USA
A. Wagner K.; Department of Neurological Surgery University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USA
R. Clark S.B.; Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USA
P. Kochanek M.; Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USA
H. Bayir ; Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USA
R. Berger P.; Department of Pediatrics Children's Hospital of Pittsburgh Pittsburgh, Pennsylvania, USA
C. Dixon E.; Department of Neurological Surgery University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USA
L. Jenkins ; Department of Neurological Surgery University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USA
A. Kline E.; Department of Neurological Surgery University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USA
S. Tisherman ; Departments of Surgery and Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USA
A. Wagner K.; Department of Neurological Surgery University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USA
R. Clark S.B.; Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USA
 
Subject Traumatic Brain Injury; Resuscitation; Child Abuse; Inflicted Childhood Neurotrauma; Hemorrhagic Shock; Emergency Preservation and Resuscitation; Apoptosis; Adenosine; Proteomics
Traumatic Brain Injury; Resuscitation; Child Abuse; Inflicted Childhood Neurotrauma; Hemorrhagic Shock; Emergency Preservation and Resuscitation; Apoptosis; Adenosine; Proteomics
 
Description This review, written on the occasion of the 70th anniversary of the Institute for General Reanimatology of the Russian Academy of Medical Sciences, provides an update of recent research in the field of resuscitation medicine carried out at the Safar Center for Resuscitation Research at the University of Pittsburgh School of Medicine. Current and recent studies describing bench to bedside investigation in the areas of traumatic brain injury (TBI), cardiopulmonary arrest, hemorrhagic shock, and ultra-novel approaches to resuscitation are discussed. Investigation in TBI across a variety of topics by many investigators including mechanism of neuronal death, oxidative and nitrative stress, proteomics, adenosine, serotonin, novel magnetic resonance imaging application, inflicted childhood neurotrauma, and TBI rehabilitation is addressed. Research discussed in the program of cardiopulmonary arrest includes optimization of the use of mild hypothermia and novel investigation in experimental asphyxial cardiac arrest. In the program on hemorrhagic shock, our recent work on the application of mild hypothermia to prolong the «golden hour» is presented. Finally, a brief overview of our studies of a novel approach to the resuscitation of exsan-guination cardiac arrest using emergency preservation for resuscitation (EPR) is provided.
This review, written on the occasion of the 70 th anniversary of the Institute for General Reanimatology of the Russian Academy of Medical Sciences, provides an update of recent research in the field of resuscitation medicine carried out at the Safar Center for Resuscitation Research at the University of Pittsburgh School of Medicine. Current and recent studies describing bench to bedside investigation in the areas of traumatic brain injury (TBI), cardiopulmonary arrest, hemorrhagic shock, and ultranovel approaches to resuscitation are discussed. Investigation in TBI across a variety of topics by many investigators including mechanism of neuronal death, oxidative and nitrative stress, proteomics, adenosine, serotonin, novel magnetic resonance imaging application, inflicted childhood neurotrauma, and TBI rehabilitation is addressed. Research discussed in the program of  cardiopulmonary  arrest  includes  optimization  of  the  use  of  mild  hypothermia  and  novel  investigation  in  experimental asphyxial cardiac arrest. In the program on hemorrhagic shock, our recent work on the application of mild hypothermia to prolong the «golden hour» is presented. Finally, a brief overview of our studies of a novel approach to the resuscitation of exsanguination  cardiac  arrest  using  emergency  preservation  for  resuscitation  (EPR)  is  provided. 
 
Publisher FSBI "SRIGR" RAMS
 
Contributor —
—
 
Date 2006-12-20
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Рецензированная статья
 
Format application/pdf
 
Identifier http://www.reanimatology.com/rmt/article/view/1355
10.15360/1813-9779-2006-6-15-25
 
Source General Reanimatology; Том II № 5-6 2006 г.; 15-25
Общая реаниматология; Том II № 5-6 2006 г.; 15-25
2411-7110
1813-9779
10.15360/1813-9779-2006-6
 
Language eng
 
Relation http://www.reanimatology.com/rmt/article/view/1355/601
 
Rights Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication, with the work 6 month after publication simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Авторы, публикующие статьи в данном журнале, соглашаются на следующее:Авторы сохраняют за собой автороские права и предоставляют журналу право первой публикации работы, которая по истечении 6 месяцев после публикации автоматически лицензируется на условиях Creative Commons Attribution License , которая позволяет другим распространять данную работу с обязательным сохранением ссылок на авторов оригинальной работы и оригинальную публикацию в этом журнале.Авторы имеют право размещать их работу в сети Интернет (например в институтском хранилище или персональном сайте) до и во время процесса рассмотрения ее данным журналом, так как это может привести к продуктивному обсуждению и большему количеству ссылок на данную работу (См. The Effect of Open Access).