Thrombolysis for Prevention of Cerebral No-Reflow After Cardiopulmonary Resuscitation
General Reanimatology
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Title |
Thrombolysis for Prevention of Cerebral No-Reflow After Cardiopulmonary Resuscitation
Thrombolysis for Prevention of Cerebral No-Reflow After Cardiopulmonary Resuscitation |
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Creator |
K. Hossmann -A.
V. Hossmann B. Bottiger W. K. Hossmann -A. V. Hossmann B. Bottiger W. |
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Subject |
cardiac arrest; no-reflow phenomenon; neurological recovery; disseminated intravascular coagulation; thrombolysis.
cardiac arrest; no-reflow phenomenon; neurological recovery; disseminated intravascular coagulation; thrombolysis. |
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Description |
Thrombolytic treatment during cardiopulmonary resuscitation is thought to reverse the cerebral no-reflow phenomenon which is widely considered to limit neurological recovery after prolonged cardio-circulatory arrest. However, the recent multicenter randomized double-blind TROICA (Thrombolysis in Cardiac Arrest) trial revealed that patients with witnessed out-of-hospital cardiac arrest did not experience an improvement of neurological outcome when treated with the throm-bolytic agent tenecteplase [1]. This raises the question of the importance of coagulation disturbances in the pathophysiol-ogy of no-reflow and its reversal by thrombolytic interventions. This article provides an overview of the experimental literature on this subject.
Thrombolytic treatment during cardiopulmonary resuscitation is thought to reverse the cerebral no-reflow phenomenon which is widely considered to limit neurological recovery after prolonged cardio-circulatory arrest. However, the recent multicenter randomized double-blind TROICA (Thrombolysis in Cardiac Arrest) trial revealed that patients with witnessed out-of-hospital cardiac arrest did not experience an improvement of neurological outcome when treated with the thrombolytic agent tenecteplase [1]. This raises the question of the importance of coagulation disturbances in the pathophysiology of no-reflow and its reversal by thrombolytic interventions. This article provides an overview of the experimental literature on this subject. |
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Publisher |
FSBI "SRIGR" RAMS
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Contributor |
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Date |
2009-04-20
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Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion Рецензированная статья |
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Format |
application/pdf
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Identifier |
http://www.reanimatology.com/rmt/article/view/594
10.15360/1813-9779-2009-2-31 |
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Source |
General Reanimatology; Том V № 2 2009 г.; 31
Общая реаниматология; Том V № 2 2009 г.; 31 2411-7110 1813-9779 10.15360/1813-9779-2009-2 |
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Language |
eng
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Relation |
http://www.reanimatology.com/rmt/article/view/594/394
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Rights |
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