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MECHANISMS OF RENAL SCARING FROM REFLUX-NEPHROPATHY

Herald Urology

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Title MECHANISMS OF RENAL SCARING FROM REFLUX-NEPHROPATHY
МЕХАНИЗМЫ ПОВРЕЖДЕНИЯ ПОЧЕЧНОЙ ПАРЕНХИМЫ ПРИ РЕФЛЮКС-НЕФРОПАТИИ
 
Creator M. Batyushin M.; Department of Internal Disease with Physiotherapy №2, Problematic Science Laboratory of Experimental Nephrology Rostov State Medical University, Rostov-on-Don South Federal University, Science Institution of Biology
М. Батюшин М.; Кафедра внутренних болезней с основами физиотерапии №2,
Проблемная научная лаборатория экспериментальной нефрологии
ГБОУ ВПО РостГМУ Минздрава России, г.Ростов-на-Дону
ФГАОУ ВПО «Южный федеральный университет»,
Научно-исследовательский институт биологии
 
Subject vesico-ureteral reflux; reflux-nephropathy; cytokines; renal scaring; urinary tract infection
везико-уретеральный рефлюкс; рефлюкс-нефропатия; цитокины; повреждение почечной ткани; инфекция мочевых путей
 
Description There is presentation of paths of the pathogenesis of renal scaring from vesico-ureteral reflux at this article. Author demonstrated the role of macrophage and tissue monocyte in process of the inflammatory remodeling of interstitial renal tissue. Different cell signals affects interstitial tissue and activates fibroblast ploliferation and interstitial volume increasing. Cytokines such us monocyte chemotactic peptide-1, epidermal growth factor, macrophage colony stimulating factor, transforming growth factor-β1plays important role within process renal scaring and remodeling. Urinary tract infection causes expressed medullar renal scaring by toxins and inductive endogenic cytokines. 
В статье представлены пути патогенеза повреждения почечной ткани в результате везико-уретерального рефлюкса. Автором показана роль макрофагов и тканевых моноци- тов в процессе воспалительного ремоделирования интерстициальной почечной ткани. Клеточные сигналы, воздействуя на интерстициальную ткань, активизируют пролифи- рацию фибробластов и приводят к увеличению интерстициального объема. Цитокины, такие как моноцитарный хемотаксический пептид-1, эпидермальный фактор роста, макрофагальный колониестимулирующий фактор, трансформирующий фактор роста β играют важную роль в процессах повреждения и перестройки почечной ткани. Инфекции мочевых путей приводят к выраженным медуллярным почечным повреждениям путем воздействия токсинов и индуктивных эндогенных цитокинов. 
 
Publisher SEI of HPE, RSMU Ministry of Health, Russia
 
Contributor —
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Date 2016-02-23
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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Format application/pdf
 
Identifier http://www.urovest.ru/jour/article/view/46
 
Source Herald Urology; № 2 (2013); 43-51
Вестник урологии; № 2 (2013); 43-51
2308-6424
 
Language rus
 
Relation http://www.urovest.ru/jour/article/view/46/50
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