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Osteoarthritis and age. Role of aging in the etiology and pathogenesis of the disease

Modern Rheumatology Journal

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Title Osteoarthritis and age. Role of aging in the etiology and pathogenesis of the disease
Остеоартрит и возраст. Роль старения в этиологии и патогенезе заболевания
 
Creator L. Luchikhina V.; N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
O. Mendel I.; N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
V. Mendel ; N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
G. Golukhov N.; N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Л. Лучихина В.; ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России
О. Мендель И.; ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России
В. Мендель ; ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России
Г. Голухов Н.; ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России
 
Subject aging; osteoarthriris; immunosenescence; inflammaging; cytokines
старение; остеоартрит; старение иммунитета (immunosenescence); инфламэйджинг (inflammaging); цитокины
 
Description The paper considers current views on the mechanisms for the development and progression of osteoarthritis (OA) and gives the definition of the disease. It describes the processes underlying aging and OA at the molecular and cellular level, with emphasis on the role of chronic nonspecific inflammation. The possible mechanisms of chronic age-related inflammation (inflammaging), the mainstay of which is systemic aging of the immune system, are characterized. On the basis of the data available in the literature, it is concluded that aging and OA have common intracellular transcription cascades and pathophysiological mechanisms: chronic nonspecific inflammation and metabolic disorders are substantially implicated in the pathogenesis of these conditions. Metabolic and structural changes occurring in the cartilage and other tissues of the locomotor apparatus with aging are noted to serve as a favorable platform for the further development and progression of OA.
В статье рассмотрены современные представления о механизмах развития и прогрессирования остеоартрита (ОА), дана дефиниция заболевания. На молекулярном и клеточном уровне описаны процессы, лежащие в основе старения и ОА, с акцентом на роль хронического неспецифического воспаления. Охарактеризованы возможные механизмы развития хронического возраст-ассоциированного воспаления (inflammaging/инфламэйджинг), базовым из которых является общее старение системы иммунитета. На основании данных литературы сделан вывод о том, что старение и ОА имеют общие каскады внутриклеточной транскрипции и патофизиологические механизмы: хроническое неспецифическое воспаление и метаболические нарушения существенно вовлечены в патогенез этих состояний. Отмечено, что метаболические и структурные изменения, происходящие в хряще и других тканях опорно-двигательного аппарата при старении, служат благоприятной платформой для дальнейшего развития и прогрессирования ОА
 
Publisher IMA-PRESS, LLC
 
Contributor —
—
 
Date 2017-03-24
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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Format application/pdf
 
Identifier http://mrj.ima-press.net/mrj/article/view/731
10.14412/1996-7012-2017-1-4-11
 
Source Modern Rheumatology Journal; Том 11, № 1 (2017); 4-11
Современная ревматология; Том 11, № 1 (2017); 4-11
2310-158X
1996-7012
10.14412/1996-7012-2017-1
 
Language rus
 
Relation http://mrj.ima-press.net/mrj/article/view/731/707
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