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CARDIOPROTECTIVE EFFECTS OF ISCHEMIC CONDITIONING. UP-TO-DATE INFORMATION IN PHYSIOLOGY, EXPERIMENTAL EVIDENCES AND CLINICAL APPLICATIONS

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Title CARDIOPROTECTIVE EFFECTS OF ISCHEMIC CONDITIONING. UP-TO-DATE INFORMATION IN PHYSIOLOGY, EXPERIMENTAL EVIDENCES AND CLINICAL APPLICATIONS
КАРДИОПРОТЕКТИВНЫЕ ЭФФЕКТЫ ИШЕМИЧЕСКОГО КОНДИЦИОНИРОВАНИЯ: СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О МЕХАНИЗМАХ, ЭКСПЕРИМЕНТАЛЬНЫЕ ПОДТВЕРЖДЕНИЯ, КЛИНИЧЕСКАЯ РЕАЛИЗАЦИЯ
 
Creator A. Bautin E.; Federal Almazov North-West Medical Research Centre
L. Karpova I.; Federal Almazov North-West Medical Research Centre
A. Marichev O.; Federal Almazov North-West Medical Research Centre
D. Tashkhanov M.; Federal Almazov North-West Medical Research Centre
V. Naumenko S.; Federal Almazov North-West Medical Research Centre
M. Galagudza M.; Federal Almazov North-West Medical Research Centre
Андрей Баутин Евгеньевич; Северо-Западный Федеральный медицинский исследовательский центр им. В.А. Алмазова
Людмила Карпова Игоревна; Северо-Западный Федеральный медицинский исследовательский центр им. В.А. Алмазова
Александр Маричев Олегович; Северо-Западный Федеральный медицинский исследовательский центр им. В.А. Алмазова
Дмитрий Ташханов Маратович; Северо-Западный Федеральный медицинский исследовательский центр им. В.А. Алмазова
Виталий Науменко Сергеевич; Северо-Западный Федеральный медицинский исследовательский центр им. В.А. Алмазова
Михаил Галагудза Михайлович; Северо-Западный Федеральный медицинский исследовательский центр им. В.А. Алмазова
 
Subject ишемическое кондиционирование; ишемическое дистантное прекондиционирование; ишемическое посткондиционирование; кардиопротекция; кардиохирургия; ischemic conditioning; remote hemic preconditioning; ischemic postconditioning; cardioprotection; cardiac surgery
 
Description Ischemic conditioning has been applied before or after an ischemic insult to the myocardium and has taken the form of local induction of ischemia or ischemia of distant tissues. The aim of this article is to review the up-to-date information in physiological mechanism of ischemic conditioning and experimental evidences of it cardioprotective effects. Additionally, the review discusses the results of recent clinical trials of different types of ischemic preconditioning.
Ишемическое кондиционирование предполагает индукцию органопротекции при выполнении коротких эпизодов ишемии-реперфузии до или после основного события ишемии. В обзоре рассматриваются современные представления о механизмах развития кардиопротективного действия различных вариантов этой нефармакологической методики, представлены экспериментальные данные, подтверждающие ее эффективность. Кроме того, в статье приведен анализ результатов клинических исследований применения ишемического кондиционирования в различных областях кардиохирургии.
 
Publisher Federal Almazov North-West Medical Research Centre, Saint Petersburg, Russia
 
Date 2016-12-23
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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Format application/pdf
 
Identifier http://transmed.almazovcentre.ru/jour/article/view/164
 
Source Translational Medicine; Том 3, № 1 (2016); 50-62
Трансляционная медицина; Том 3, № 1 (2016); 50-62
2410-5155
2311-4495
 
Language rus
 
Relation http://transmed.almazovcentre.ru/jour/article/view/164/165
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