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CHANGES IN CIRCULATING MICRORNA LEVELS DURING PATHOGENESIS OF GENETICALLY DETERMINED MATURITY ONSET DIABETES OF THE YOUNG

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Title CHANGES IN CIRCULATING MICRORNA LEVELS DURING PATHOGENESIS OF GENETICALLY DETERMINED MATURITY ONSET DIABETES OF THE YOUNG
ИЗМЕНЕНИЕ УРОВНЕЙ ЦИРКУЛИРУЮЩИХ МИКРОРНК ПРИ ПАТОГЕНЕЗЕ ГЕНЕТИЧЕСКИ ОБУСЛОВЛЕННОГО САХАРНОГО ДИАБЕТА ВЗРОСЛЫХ У МОЛОДЫХ
 
Creator T. Petrova A.; Federal Almazov North-West Medical Research Centre
K. Kondratov A.; Federal Almazov North-West Medical Research Centre
A. Fedorov V.; Federal Almazov North-West Medical Research Centre
I. Nikitina L.; Federal Almazov North-West Medical Research Centre
I. Artemeva Y.; Federal Almazov North-West Medical Research Centre
A. Kostareva A.; Federal Almazov North-West Medical Research Centre
Т. Петрова А.; Северо-Западный федеральный медицинский исследовательский центр имени В. А. Алмазова
К. Кондратов А.; Северо-Западный федеральный медицинский исследовательский центр имени В. А. Алмазова
А. Федоров В.; Северо-Западный федеральный медицинский исследовательский центр имени В. А. Алмазова
И. Никитина Л.; Северо-Западный федеральный медицинский исследовательский центр имени В. А. Алмазова
И. Артемьева Ю.; Северо-Западный федеральный медицинский исследовательский центр имени В. А. Алмазова
А. Костарева А.; Северо-Западный федеральный медицинский исследовательский центр имени В. А. Алмазова
 
Subject maturity onset diabetes of the young; MODY; microRNAs; biomarkers
сахарный диабет взрослого типа у молодых; MODY-диабет; микроРНК; биомаркеры
 
Description Maturity onset diabetes of the young or MODY is one of the monogenic forms of inherited diabetes, caused by genetic abnormalities in beta cells. Soft manifestation and overlapping clinical symptoms of MODY with common types of diabetes often lead to difficulties in diagnosis. One of the main criteria of correct MODY diagnosis is identification of causative mutations in MODY-related genes. Correct MODY diagnosis enable to apply more specific treatment strategies and identify unobvious cases of the disease by testing relatives of the patients. Circulating microRNAs are promising candidates for early diagnostic biomarkers of the disease. The review focuses on current literature data about MODY-associated microRNA types and their levels in diverse body fluids, which help to identify asymptomatic patients with different MODY types. 
Сахарный диабет взрослого типа у молодых или MODY-диабет представляет собой моногенную форму диабета, возникающую при генетических нарушениях функционирования β-клеток поджелудочной железы. Сложность диагностирования данного типа диабета состоит в мягком проявлении заболевания и перекрывании клинических симптомов MODY-диабета с симптомами диабетов других типов. Одним из основных критериев постановки диагноза MODY-диабет является обнаружение мутации в генах, связанных с механизмами регуляции синтеза и секреции инсулина. Диагностика MODY-диабета позволяет применять более специфичные схемы лечения, а также выявлять новые случаи данного заболевания, проверяя родственников пациентов. Перспективную группу новых биомаркеров для ранней диагностики данного заболевания представляют собой циркулирующие микроРНК. Данная статья посвящена обзору имеющейся на сегодняшний день информации о микроРНК, уровни которых в биологических жидкостях позволяют выявлять пациентов с различными типами MODY-диабета.
 
Publisher Federal Almazov North-West Medical Research Centre, Saint Petersburg, Russia
 
Contributor —
—
 
Date 2017-04-05
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://transmed.almazovcentre.ru/jour/article/view/268
 
Source Translational Medicine; Том 3, № 6 (2016); 15-20
Трансляционная медицина; Том 3, № 6 (2016); 15-20
2410-5155
2311-4495
 
Language rus
 
Relation http://transmed.almazovcentre.ru/jour/article/view/268/230
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