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Review of experimental animal models to study mechanisms of acute graft versus host disease (GVHD)

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Title Review of experimental animal models to study mechanisms of acute graft versus host disease (GVHD)
Экспериментальные модели изучения механизмов острой реакции трансплантат против хозяина (РтПх) на грызунах
 
Creator P Butylin ; Federal Almazov North-West Research Centre
R. Badaev .; Federal Almazov North-West Research Centre
D. Motorin .; Federal Almazov North-West Research Centre
Павел Бутылин Андреевич; Федеральное государственное бюджетное учреждение «Северо-Западный федеральный медицинский исследовательский центр»
Ренат Бадаев Шамилевич; Федеральное государственное бюджетное учреждение «Северо-Западный федеральный медицинский исследовательский центр»
Дмитрий Моторин Васильевич; Федеральное государственное бюджетное учреждение «Северо-Западный федеральный медицинский исследовательский центр»
 
Subject аллогенная пересадка гемопоэтических стволовых клеток (алло ТГСК); реакция трансплантат против хозяина (РТПХ); ксеногенная трансплантация; экспериментальные модели; иммунодефицитные мыши; allogeneic transplantation of hematopoietic stem cells (ALLO HSCT); graft-versus-host disease (GVHD); xenogeneic transplantation; experimental models; immunodeficient mice
 
Description Hematopoietic stem cell transplantation (HSCT) is a necessary and sometimes the only available treatment for the many of the patients with hematological neoplasms. Development of the technologies and protocols for allows broadening of the spectrum of patients that could be treated with allogenic HSCT. One of the main complications in allogenic HSCT is immune conflict of the donor cells with patient’s tissues, named graft versus host disease (GVHD). Key studies of the mechanisms of GVHD are made in experimental models of transplantation in transgenic mice. This paper review current models of acute GVHD that helps to study mechanisms of GVHD and develop new therapeutic schemes to improve efficiency, decrease adverse effects and improving overall survival rate.
Трансплантация гемопоэтических стволовых клеток - необходимая, и подчас единственная возможность излечения для многих пациентов с онкогематологическими заболеваниями. Современное развитие медицинских технологий всё больше расширяет спектр показаний к аллогенной трансплантации ГСК. Наряду с успехами в проведении трансплантаций остаются нерешенными ряд вопросов, касающихся осложнений после трансплантации. Одним из основных осложнений при аллогенной ТГСК является развитие имунного конфликта между клетками донора и тканями реципиента, получившего название реакции трансплантат против хозяина (РТПХ). Ключевые исследования механизмов РТПХ проводятся на модельных животных, в первую очередь на трансгенных мышах. Данный обзор посвящен обзору исследовательских моделей острой РТПХ, использование которых позволяет расширить знания о патогененезе этого явления и исследовать новые терапевтические схемы.
 
Publisher Federal Almazov North-West Medical Research Centre, Saint Petersburg, Russia
 
Date 2016-12-23
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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Format application/pdf
 
Identifier http://transmed.almazovcentre.ru/jour/article/view/74
 
Source Translational Medicine; № 2-3 (2015); 90-97
Трансляционная медицина; № 2-3 (2015); 90-97
2410-5155
2311-4495
 
Language rus
 
Relation http://transmed.almazovcentre.ru/jour/article/view/74/75
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