Amiodarone in cardiac transplant waiting list patients with severe heart failure
Russian Journal of Transplantology and Artificial Organs
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Title |
Amiodarone in cardiac transplant waiting list patients with severe heart failure
Использование амиодарона у реципиентов в листе ожидания трансплантации сердц |
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Creator |
N. Koloskova N.; V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation
V. Poptsov N.; V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation G. Salikhova M.; V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation Н. Колоскова Н.; ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России В. Попцов Н.; ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России Г. Салихова М.; ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России |
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Subject |
amiodarone;cardiac recipient survival;drug interaction;heart transplantation;immunosuppressive therapy
амиодарон;выживаемость реципиентов;лекарственное взаимодействие;трансплантация сердца;иммуносупрессивная терапия |
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Description |
Heart transplantation is the «gold standard» of severe heart failure treatment. Sudden arrhythmic death is the leading cause of death among these patients. Amiodarone is the only antiarrhythmic drug with beneficial effect on survival of patients with end-stage heart failure. Given its long half-life, pre-transplant use of amiodarone has been extensively discussed focusing on divergent results regarding morbidity and mortality after heart transplantation. Its adverse clinical events after transplantation remain debatable. This review is aimed at evaluation of the impact of amiodarone pretransplant use on mortality and complications after heart transplantation.
Единственным радикальным методом лечения хронической сердечной недостаточности остается трансплантация сердца. В качестве профилактики внезапной сердечной смерти и лечения желудочковых нарушений ритма у пациентов с терминальной стадией сердечной недостаточности широко используется антиаритмическая терапия амиодароном. Учитывая длительный период полувыведения препарата из организма, его влияние на течение послеоперационного периода, функцию трансплантата и показатели выживаемости остается дискутабельным. Цель настоящего обзора – проанализировать данные литературы, касающиеся влияния предтрансплантационного применения амиодарона на течение послеоперационного периода, функцию трансплантата и летальность в ранние сроки после трансплантации сердца. |
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Publisher |
V.I.Shumakov Federal Research Center of Transplantology and Artificial Organs
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Contributor |
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Date |
2017-06-23
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Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion — — |
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Format |
application/pdf
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Identifier |
http://journal.transpl.ru/vtio/article/view/761
10.15825/1995-1191-2017-2-133-138 |
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Source |
Russian Journal of Transplantology and Artificial Organs; Том 19, № 2 (2017); 133-138
Вестник трансплантологии и искусственных органов; Том 19, № 2 (2017); 133-138 2412-6160 1995-1191 10.15825/1995-1191-2017-2 |
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Language |
rus
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Relation |
http://journal.transpl.ru/vtio/article/view/761/638
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