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The mechanism of humoral immune response to allogeneic organ transplantation

Russian Journal of Transplantology and Artificial Organs

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Title The mechanism of humoral immune response to allogeneic organ transplantation
Механизм развития гуморального иммунного ответа на аллогенную трансплантацию орг
 
Creator A. Berkos S.; Russian Research Institute of Hematology and Transfusiology
G. Nikolaev V.; Federal State Budgetary Institution Federal Almazov North-West Medical Research Centre of the Ministry of Healthcare of the Russian Federation
А. Беркос С.; ФГБУ «Российский НИИ гематологии и трансфузиологии ФМБА России»
Г. Николаев В.; ФГБУ «Северо-Западный федеральный медицинский исследовательский центр» Минздрава России
 
Subject humoral rejection;allograft;HLA-antigens;B-cell receptors;germinal centers;epitopes;crossreactivity
гуморальное отторжение;аллогенный трансплантат;HLA-антигены;В-клеточные рецепторы;герминативные центры;эпитопы;кросс-реактивность
 
Description The problem of antibody-mediated rejection of donor organ remains extremely relevant. The main targets of the antibodies are mainly donor HLA-antigens (Human Leucocyte Antigens), expressed, in particular, by the cells of graft vascular endothelium. This review describes the mechanisms of the development of humoral alloimmunity which are based on B-cell recognition of epitopes of donor HLA-molecules and affinity maturation of B-cell receptors in the germinal centers of peripheral lymphatic system. Monitoring of epitope load and cross-reactivity indicators to evaluate HLA-compatibility of donor and recipient plays an important role in the prevention of allograft humoral rejection.
Проблема гуморального, антителоопосредованного отторжения донорского органа остается крайне актуальной. Главной мишенью антител в основном являются донорские HLA-антигены (Human Leucocyte Antigens), экспрессируемые, в частности, клетками сосудистого эндотелия трансплантата. В данном обзоре рассматриваются механизмы развития гуморального аллоиммунитета, в основе которых лежит распознавание В-клетками реципиента эпитопов донорских HLA-молекул и созревание аффинности В‑клеточных рецепторов в герминативных центрах периферической лимфатической системы. Учет показателей эпитопной нагрузки и кросс-реактивности при анализе HLA-совместимости донора и реципиента играет важную роль в профилактике гуморального отторжения аллогенного трансплантата.
 
Publisher V.I.Shumakov Federal Research Center of Transplantology and Artificial Organs
 
Contributor —
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Date 2017-06-23
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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Format application/pdf
 
Identifier http://journal.transpl.ru/vtio/article/view/762
10.15825/1995-1191-2017-2-139-151
 
Source Russian Journal of Transplantology and Artificial Organs; Том 19, № 2 (2017); 139-151
Вестник трансплантологии и искусственных органов; Том 19, № 2 (2017); 139-151
2412-6160
1995-1191
10.15825/1995-1191-2017-2
 
Language rus
 
Relation http://journal.transpl.ru/vtio/article/view/762/639
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