SEROLOGICAL DIAGNOSIS OF MODERN CHOLERA USING LIPOSOMAL ENTEROTOXIC DIAGNOSTICUM IN COMPLEMENT FIXATION TEST
Medical Immunology
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| Title |
SEROLOGICAL DIAGNOSIS OF MODERN CHOLERA USING LIPOSOMAL ENTEROTOXIC DIAGNOSTICUM IN COMPLEMENT FIXATION TEST
СЕРОЛОГИЧЕСКАЯ ДИАГНОСТИКА СОВРЕМЕННОЙ ХОЛЕРЫ С ИСПОЛЬЗОВАНИЕМ ЛИПОСОМАЛЬНОГО ЭНТЕРОТОКСИЧЕСКОГО ДИАГНОСТИКУМА В РЕАКЦИИ СВЯЗЫВАНИЯ КОМПЛЕМЕНТА |
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| Creator |
I. Savelyeva V.; The Federal Government Public Health Institution “Stavropol Institute for Plague Control of the Rospotrebnadzor”, Stavropol
V. Bezsmertnyj E.; The Federal Government Public Health Institution “Anti-plague Centre of the Rospotrebnadzor”, Moscow V. Savelyev N.; The Federal Government Public Health Institution “Stavropol Institute for Plague Control of the Rospotrebnadzor”, Stavropol Yu. Fedorov M.; The Federal Government Public Health Institution “Anti-plague Centre of the Rospotrebnadzor”, Moscow C. Ivanova M.; The Federal Government Public Health Institution “Anti-plague Centre of the Rospotrebnadzor”, Moscow V. Ivannikov V.; The Federal Government Public Health Institution “Anti-plague Centre of the Rospotrebnadzor”, Moscow И. Савельева В.; ФКУЗ Ставропольский противочумный институт Роспотребнадзора, г. Ставрополь В. Безсмертный Е.; ФКУЗ Противочумный центр Роспотребнадзора, Москва В. Савельев Н.; ФКУЗ Ставропольский противочумный институт Роспотребнадзора, г. Ставрополь Ю. Федоров М.; ФКУЗ Противочумный центр Роспотребнадзора, Москва С. Иванова М.; ФКУЗ Противочумный центр Роспотребнадзора, Москва В. Иванников В.; ФКУЗ Противочумный центр Роспотребнадзора, Москва |
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| Subject |
serological diagnosis; cholera; liposomal diagnosticum; direct complement fixation test
серологическая диагностика; холера; липосомальный диагностикум; РСК |
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| Description |
Abstract. The possibility of serological diagnosis of cholera using cholera enterotoxic diagnostics kit in complement fixation test to detect anti-enterotoxic antibodies in sera of patients with cholera caused by hybrid variants of the El Tor biovar has been demonstrated. In patients with mild course of cholera anti-enterotoxic antibodies were detected in titres 1:50 and 1:200 in paired sera obtained on the 7th and 14th days of disease, respectively (fourfold titre increase). In patients with the course of medium severity 32-fold titre increase was recorded from the titre 1:100 in serum obtained on the fifth day of disease till the titre 1:3200 — on the twelfth day of disease. Antibodies titers reached 1:1600 and 1:800 were revealed in two medium course patients (adult and infant of 10 months) on the sixth day of disease.
Резюме.Показана возможность серологической диагностики холеры путем применения липосомального холерного энтеротоксического диагностикума в реакции связывания комплемента с целью определения антиэнтеротоксических антител в сыворотке крови больных холерой, обусловленной гибридными вариантами биовара эльтор. Так, при легком течении болезни холерные антиэнтеротоксические антитела выявлены в парных сыворотках крови, взятой на 7 и 14 дни болезни, в титрах соответственно 1:50 и 1:200 (4-кратное увеличение титра), при среднетяжелом течении — 1:100 (пятый день болезни) и 1:3200 (двенадцатый день болезни) (32-кратное увеличение титра). У двух больных на 6-й день со среднетяжелым течением болезни антитела выявлены в титрах 1:1600 (у взрослого) и 1:800 (у ребенка 10 месяцев). |
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| Publisher |
Publishing house of Saint Petersburg Pasteur Institute
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—
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| Date |
2014-07-11
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion — — |
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| Format |
application/pdf
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| Identifier |
http://iimmun.ru/index.php/iimm/article/view/177
10.15789/2220-7619-2013-3-285–288 |
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| Source |
Russian Journal of Infection and Immunity; Том 3, № 3 (2013); 285–288
Инфекция и иммунитет; Том 3, № 3 (2013); 285–288 2313-7398 2220-7619 10.15789/2220-7619-2013-3 |
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| Language |
rus
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| Relation |
http://iimmun.ru/index.php/iimm/article/view/177/176
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| Rights |
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