THE INTERDEPENDENCE OF THE CYTOKINE STATUS AND THE SEVERITY OF INTOXICATION SYNDROME IN INFLUENZA
Medical Immunology
View Archive Info| Field | Value | |
| Title |
THE INTERDEPENDENCE OF THE CYTOKINE STATUS AND THE SEVERITY OF INTOXICATION SYNDROME IN INFLUENZA
ВЗАИМОСВЯЗЬ ЦИТОКИНОВОГО СТАТУСА И ВЫРАЖЕННОСТИ ИНТОКСИКАЦИОННОГО СИНДРОМА ПРИ ГРИППЕ |
|
| Creator |
L. Voloschcuk V.; Ministry of Health of the Russian Federation Research Institute of Influenza, Saint Petersburg
E. Golovacheva G.; Ministry of Health of the Russian Federation Research Institute of Influenza, Saint Petersburg A. Mushkatina L.; Ministry of Health of the Russian Federation Research Institute of Influenza, Saint Petersburg L. Osidak V.; Ministry of Health of the Russian Federation Research Institute of Influenza, Saint Petersburg P. Zarishnuk V.; Ministry of Health of the Russian Federation Research Institute of Influenza, Saint Petersburg A. Go A.; Ministry of Health of the Russian Federation Research Institute of Influenza, Saint Petersburg Л. Волощук В.; ФГБУ НИИ гриппа Минздрава РФ, Санкт-Петербург Е. Головачева Г.; ФГБУ НИИ гриппа Минздрава РФ, Санкт-Петербург А. Мушкатина Л.; ФГБУ НИИ гриппа Минздрава РФ, Санкт-Петербург Л. Осидак В.; ФГБУ НИИ гриппа Минздрава РФ, Санкт-Петербург П. Заришнюк В.; ФГБУ НИИ гриппа Минздрава РФ, Санкт-Петербург А. Го А.; ФГБУ НИИ гриппа Минздрава РФ, Санкт-Петербург |
|
| Subject |
influenza; cytokines; intoxicant stresses syndrome
грипп; цитокины; интоксикационный синдром |
|
| Description |
Abstract. The goal of study was to evaluate cytokines level in blood of 60 patients with uncomplicated influenza and its relations with severity of intoxication symptoms. High level of TNFα, IL-10, IL-1Rа and low level of IFNγ was measured in serum of patients with severe intoxication syndrome during acute phase of disease. The duration of intoxication syndrome of influenza had a direct correlation with the concentration of TNFα, IL-6, IL-8, IL-1Rа, IL-10 and the opposite of IL-1β.
Резюме. Целью настоящего исследования было изучение содержания цитокинов и интерферонов в сыворотке крови при неосложненном гриппе в зависимости от выраженности интоксикационного синдрома у 60 человек. Показано, что выраженный интоксикационный синдром в острый период заболевания сопровождается высокой концентрацией TNFα, IL-10, IL-1Rа и снижением содержания IFNγ в сыворотке крови. Продолжительность интоксикационного синдрома при гриппе имела прямую корреляционную связь с концентрацией TNFα, IL-6, IL-8, IL-1Rа, IL-10 и обратную c IL-1β. |
|
| Publisher |
Publishing house of Saint Petersburg Pasteur Institute
|
|
| Contributor |
—
— |
|
| Date |
2014-07-11
|
|
| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion — — |
|
| Format |
application/pdf
|
|
| Identifier |
http://iimmun.ru/index.php/iimm/article/view/173
10.15789/2220-7619-2013-3-263-268 |
|
| Source |
Russian Journal of Infection and Immunity; Том 3, № 3 (2013); 263-268
Инфекция и иммунитет; Том 3, № 3 (2013); 263-268 2313-7398 2220-7619 10.15789/2220-7619-2013-3 |
|
| Language |
rus
|
|
| Relation |
http://iimmun.ru/index.php/iimm/article/view/173/172
|
|
| Rights |
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
|
|