ASSESSMENT OF THE SPECIFIC LOCAL HUMORAL IMMUNITY IN PATIENTS WITH INFERTILITY INCLUDING CASES ASSOCIATED WITH GENITAL TUBERCULOSIS
Medical Immunology
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| Title |
ASSESSMENT OF THE SPECIFIC LOCAL HUMORAL IMMUNITY IN PATIENTS WITH INFERTILITY INCLUDING CASES ASSOCIATED WITH GENITAL TUBERCULOSIS
ОЦЕНКА СОСТОЯНИЯ ЛОКАЛЬНОГО СПЕЦИФИЧЕСКОГО ГУМОРАЛЬНОГО ИММУНИТЕТА У ПАЦИЕНТОК С БЕСПЛОДИЕМ, В ТОМ ЧИСЛЕ АССОЦИИРОВАННЫМ С ГЕНИТАЛЬНЫМ ТУБЕРКУЛЕЗОМ |
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| Creator |
A. Mordyk V.; State Educational Institution of Higher Professional Education Omsk State Medical Academy of Russian Ministry of Health, Omsk T. Dolgyh I.; State Educational Institution of Higher Professional Education Omsk State Medical Academy of Russian Ministry of Health, Omsk N. Frolova B.; Departmental Hospital at the Station Omsk-Passenger, Omsk A. Yakovleva A.; State Educational Institution of Higher Professional Education Omsk State Medical Academy of Russian Ministry of Health, Omsk; Clinical Health Care Facility of the Omsk Region Clinical Anti-Tuberculosis Dispensary No. 4, Omsk А. Мордык В.; ГБОУ ВПО Омская государственная медицинская академия Минздрава России, г. Омск Т. Долгих И.; ГБОУ ВПО Омская государственная медицинская академия Минздрава России, г. Омск Н. Фролова Б.; Отделенческая клиническая больница на ст. Омск-Пассажирский, г. Омск А. Яковлева А.; ГБОУ ВПО Омская государственная медицинская академия Минздрава России, г. Омск; КУЗОО Клинический противотуберкулезный диспансер № 4, г. Омск |
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| Subject |
specific humoral immunity; infertility; genital tuberculosis; peritoneal fluid
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| Description |
Abstract. In order to optimize the detection and diagnosis of genital tuberculosis evaluation of the specific local antituberculosis immunity in 39 patients with infertility entered to the Department of Gynecology for the implementation of therapeutic and diagnostic laparoscopy has been carried out. All patients were divided into 3 groups: the 1st one included patients with tubal-peritoneal infertility, the group 2 included patients with infertility not associated with the defeat of the fallopian tubes, the third group was presented by patients with tubal-peritoneal infertility associated with genital tuberculosis who completed the basic course of anti-tuberculosis treatment. It was established that in case of the tubal-peritoneal infertility the local humoral immunity was characterised by increasing of IgM in the whole peritoneal fluid. Among women who recovered from genital tuberculosis increasing of IgA and IgG to M. tuberculosis was revealed in contrast to patients with infertility not associated with damage of fallopian tubes (p < 0.05). In 25% of patients of the 1st group genital tuberculosis was diagnosed. The diagnostic criteria for early detection of genital tuberculosis were determined and the algorithm of genital tuberculosis identification have been proposed.
Резюме. С целью оптимизации выявления и диагностики генитального туберкулеза проведена оценка специфического противотуберкулезного локального иммунитета у 39 пациенток с бесплодием, направленных в отделение гинекологии для осуществления лечебно-диагностической лапароскопии. Пациентки были разбиты на 3 группы: 1-я — пациентки с трубно-перитонеальным бесплодием, 2-я группа — с бесплодием, не ассоциированным с поражением маточных труб, 3-я группа — пациентки с трубно-перитонеальным бесплодием, связанным с генитальным туберкулезом, завершившие основной курс лечения по поводу туберкулеза. Установлено, что при трубно-перитонеальном бесплодии особенностями локального гуморального иммунитета является достоверное повышение IgM в цельной перитонеальной жидкости, среди лиц, перенесших генитальный туберкулез — повышение IgA и IgG к M. tuberculosis в отличие от больных с бесплодием, не ассоциированным с поражением маточных труб (р < 0,05). У 25% пациенток 1-й группы диагностирован генитальный туберкулез. Установлены диагностические признаки для раннего выявления генитального туберкулеза, предложен алгоритм выявления. |
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| Publisher |
Publishing house of Saint Petersburg Pasteur Institute
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| Date |
2014-07-08
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion — — |
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| Format |
application/pdf
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| Identifier |
http://iimmun.ru/index.php/iimm/article/view/142
10.15789/2220-7619-2013-4-335-340 |
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| Source |
Russian Journal of Infection and Immunity; Том 3, № 4 (2013); 335-340
Инфекция и иммунитет; Том 3, № 4 (2013); 335-340 2313-7398 2220-7619 10.15789/2220-7619-2013-4 |
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| Language |
rus
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| Relation |
http://iimmun.ru/index.php/iimm/article/view/142/141
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| Rights |
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