SPARING CYSTECTOMY IN PATIENTS WITH TRANSITIONAL-CELL CARCINOMA OF THE URINARY BLADDER
Oncourology
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| Title |
SPARING CYSTECTOMY IN PATIENTS WITH TRANSITIONAL-CELL CARCINOMA OF THE URINARY BLADDER
СПАСИТЕЛЬНАЯ ЦИСТЭКТОМИЯ У БОЛЬНЫХ ПЕРЕХОДНО-КЛЕТОЧНЫМ РАКОМ МОЧЕВОГО ПУЗЫРЯ |
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| Creator |
V. Matveyev B.; Department of Urology, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
M. Volkova I.; Department of Urology, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow K. Figurin M.; Department of Urology, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow M. Peters V.; Department of Urology, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow В. Матвеев Б.; ГУ РОНЦ им. Н.Н. Блохина РАМН, Москва М. Волкова И.; ГУ РОНЦ им. Н.Н. Блохина РАМН, Москва К. Фигурин М.; ГУ РОНЦ им. Н.Н. Блохина РАМН, Москва М. Петерс В.; ГУ РОНЦ им. Н.Н. Блохина РАМН, Москва |
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| Description |
Objective: to study the results of sparing cystectomy in patients with urinary bladder cancer (UBC).Subjects and methods. The study has covered 82 patients with transitional-cell UBC (T1-4aN0M0) who received radiotherapy (RT) and thenunderwent radical cystectomy at the N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, in 1980 to2007. Among them there were 76 (92.7%) males and 6 (7.3%) females. The median age was 55.2±10.8 years. Superficial (T1) and inva-sive (Т2—4а) carcinomas were detected in 33 (40.2%) and 49 (59.8%) patients, respectively. Category N+ was identified in 3 (3.7%) patients.All the patients received RT to the bladder area (median total focal dose (TFD) 56±12.3 Gy) and regional metastatic zones (median TFD40.0±0.0 Gy). A full effect of irradiation was achieved in 44 (53.7%) patients, of whom 41 (93.2%) developed local relapses. All the 82patients underwent radical cystectomy: that with ureterostomy in 28 (34.1%) cases, Bricker’s operation in 45 (54.4%), Studer’s operationin 4 (4.9%), and rectal urinary bladder in 5 (6.1%). The median follow-up was 32.7±31.9 months.Results. The median interval between RT and cystectomy was 12.5±5.1 months; the median time of surgery was 360 (60—480) min; themedian blood loss was 1515.2±1227.8 ml. Intraoperative and postoperative complications developed in 10 (12.2%) and 40 (48.6%)patients, respectively. Repeated operations were performed in 7 (8.4%) cases. Mortality was 4.9%. A urinary derivation technique failed toaffect the incidence of complications and the rates of mortality (p > 0.05). Histological studies revealed transitional-cell carcinoma in thedistant specimens in 80 (97.6%) cases. Recurrences developed in 40 (48.8%) of the 82 patients following an average of 32.9 (1—150)months of cystectomy: local relapses in 5 (6.1%) cases; distant metastases in 29 (35.4%); a local relapse and distant metastases in 5 (6.1%);urethral recurrence in 1 (1.2%) patient. Five-year overall, specific, and relapse-free survivals were 43.9 (median 48.4±10.5 months), 48.5(59.9±9.3 months), and 42.8% (47.4±9.6 months), respectively. Conclusion. Sparing cystectomy with any urinary derivation technique is associated with the acceptable frequency of complications and pro-vides fair long-term results in patients who show no complete effect or who have a local UBC relapse after RT.
Спасительная цистэктомия у больных переходно-клеточным раком мочевого пузыря |
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| Publisher |
"PH "ABV-Press"", LLC
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| Date |
2014-07-30
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info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion — — |
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application/pdf
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| Identifier |
http://oncourology.abvpress.ru/index.php/oncur/article/view/181
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| Source |
Oncourology; № 1 (2009); 27-31
Онкоурология; № 1 (2009); 27-31 1726-9776 |
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| Language |
rus
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| Relation |
http://oncourology.abvpress.ru/index.php/oncur/article/view/181/195
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| Rights |
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
Авторы, публикующие в данном журнале, соглашаются со следующим:Авторы сохраняют за собой авторские права на работу и предоставляют журналу право первой публикации работы на условиях лицензии Creative Commons Attribution License, которая позволяет другим распространять данную работу с обязательным сохранением ссылок на авторов оригинальной работы и оригинальную публикацию в этом журнале.Авторы сохраняют право заключать отдельные контрактные договоронности, касающиеся не-эксклюзивного распространения версии работы в опубликованном здесь виде (например, размещение ее в институтском хранилище, публикацию в книге), со ссылкой на ее оригинальную публикацию в этом журнале.Авторы имеют право размещать их работу в сети Интернет (например в институтском хранилище или персональном сайте) до и во время процесса рассмотрения ее данным журналом, так как это может привести к продуктивному обсуждению и большему количеству ссылок на данную работу (См. The Effect of Open Access). |
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